Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin
- 1 April 2003
- journal article
- review article
- Published by Taylor & Francis in Expert Review of Vaccines
- Vol. 2 (2), 253-267
- https://doi.org/10.1586/14760584.2.2.253
Abstract
The skin is an attractive target for vaccine delivery. Topical application of adjuvants results in potent immune responses and good safety profiles. Adjuvants can be coadministered in a patch with vaccine antigens (transcutaneous immunization) or similar delivery format, or administered separately with an injection or IS patch (Iomai), leading to enhanced immune responses. These observations have moved into the clinic, highlighting the likelihood that skin delivery of vaccines will play an important future role in vaccine applications.Keywords
This publication has 19 references indexed in Scilit:
- Plasmid Vectors Encoding Cholera Toxin or the Heat-Labile Enterotoxin fromEscherichia coliAre Strong Adjuvants for DNA VaccinesJournal of Virology, 2002
- Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal deliveryNature Medicine, 2002
- Safety and Immunogenicity of a Prototype EnterotoxigenicEscherichia coliVaccine Administered TranscutaneouslyInfection and Immunity, 2002
- Transcutaneous Immunization Using Colonization Factor and Heat-Labile Enterotoxin Induces Correlates of Protective Immunity for EnterotoxigenicEscherichia coliInfection and Immunity, 2002
- Protection against influenza virus challenge by topical application of influenza DNA vaccineVaccine, 2001
- Safety and Immunogenicity of Oral Inactivated Whole-Cell Helicobacter pylori Vaccine with Adjuvant among Volunteers with or without Subclinical InfectionInfection and Immunity, 2001
- Transcutaneous immunization of domestic animals: opportunities and challengesAdvanced Drug Delivery Reviews, 2000
- Parenteral Adjuvant Activities ofEscherichia coliHeat-Labile Toxin and Its B Subunit for Immunization of Mice against GastricHelicobacter pyloriInfectionInfection and Immunity, 2000
- Immunobiology of Dendritic CellsAnnual Review of Immunology, 2000
- Field trial of a locally produced, killed, oral cholera vaccine in VietnamThe Lancet, 1997