Reliability of the 30-Minute ACTH Test in Assessing Hypothalamic-Pituitary-Adrenal Function
- 1 August 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 47 (2), 272-274
- https://doi.org/10.1210/jcem-47-2-272
Abstract
An insulin hypoglycemia test and a 30-min ACTH test were performed in 90 patients with proved or suspected hypothalamic-pituitary-adrenal hypofunction and in 10 normal subjects. The peak plasma cortisol concentration during hypoglycemia and the cortisol concentration at 30 min after injection of 250 μg corticotropin1–24 were compared. A very close correlation (r = 0.92) was found between the two concentrations, with no major discrepancy in any case. It is concluded that the short ACTH test accurately reflects the integrated hypothalamic-pituitary-adrenal function, as assessed by the insulin hypoglycemia test.Keywords
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