Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region

Abstract
Little is known about the molecular basis for the cellular and serological polymorphism of the [human] HLA-D/DR antigens, as alloantisera are usually of very low titer and heteroantisera frequently lack monospecificity. The preparation and characterization of a monoclonal antibody which defines a new polymorphic system of the HLA-D/DR region are given. This and similar antisera should now begin to provide the reagents with which to correlate molecular structure with the functional repertoire of the human Ia-like antigens.