Thiazides I. Limitations of Bratton-Marshall Colorimetric Assay Method and Its Modifications in the Determination of Chlorothiazide in Bioequivalency Studies
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 13 (2), 135-148
- https://doi.org/10.1080/00032718008067948
Abstract
The bioavailability of a commercially available 250 mg and a 500 mg chlorothiazide tablet was determined in human volunteers using cumulative urinary drug excretion. Urine specimens were analyzed for concentrations of chlorothiazide by four different modifications of the Bratton-Marshail assay procedure. Study results demonstrated that the estimation of this drug's bioavailability could vary with the particular modification used for urinary drug analysis.Keywords
This publication has 3 references indexed in Scilit:
- Determination of Hydrochlorothiazide in Urine**Received October 12, 1959, from the Research Department, Ciba Pharmaceutical Products Inc., Summit N. J.Journal of the American Pharmaceutical Association (Scientific ed.), 1960
- Studies with Chlorothiazide Tagged with Radioactive Carbon (C14) in Human BeingsArchives of Internal Medicine, 1960
- PHYSIOLOGICAL DISPOSITION OF CHLOROTHIAZIDE (DIURIL) IN THE DOG1959