Gene products required for chromosome separation
Open Access
- 1 February 1989
- journal article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 1989 (Supplement), 213-229
- https://doi.org/10.1242/jcs.1989.supplement_12.18
Abstract
Gene products required for mitotic chromosome separation in the fission yeast Schizosaccharomyces pombe are described. They have been identified by two distinct strategies of mutant isolation, followed by gene cloning and immunochemical characterization of gene products. The roles of four representative genes, namely nda3 +, nuc2 +, top2 + and dis2 +, encoding β -tubulin, a nuclear scaffold-like protein, DNA topoisomerase II and type-1 protein phosphatase, respectively, are discussed in regard to the mechanisms and control of chromosome separation.Keywords
This publication has 34 references indexed in Scilit:
- Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic controlCell, 1989
- Essential roles of the RNA polymerase I largest subunit and DNA topoisomerases in the formation of fission yeast nucleolus.The Journal of cell biology, 1989
- Two isoforms of protein phosphatase 1 may be produced from the same geneFEBS Letters, 1988
- Isolation and sequence analysis of a cDNA clone encoding a type‐1 protein phosphatase catalytic subunit: Homology with protein phosphatase 2AFEBS Letters, 1987
- DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombeCell, 1987
- Identification of the pleiotropic cell division cycle gene NDA2 as one of two different α-tubulin genes in schizosaccharomyces pombeCell, 1984
- Two cell division cycle genes NDA2 and NDA3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compoundsJournal of Molecular Biology, 1983
- Cold-sensitive nuclear division arrest mutants of the fission yeast Schizosaccharomyces pombeJournal of Molecular Biology, 1983
- [12] One-step gene disruption in yeastMethods in Enzymology, 1983
- In vivo actions of protein phosphatase inhibitor‐2 inXenopusoocytesFEBS Letters, 1982