A Complex of Soluble MD-2 and Lipopolysaccharide Serves as an Activating Ligand for Toll-like Receptor 4
Open Access
- 1 August 2004
- journal article
- Published by Elsevier
- Vol. 279 (33), 34698-34704
- https://doi.org/10.1074/jbc.m405444200
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- The immune response of DrosophilaNature, 2003
- Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal TransductionJournal of Biological Chemistry, 2003
- Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signalingNature Immunology, 2003
- Innate immune sensing and its roots: the story of endotoxinNature Reviews Immunology, 2003
- MD-2, a Novel Accessory Molecule, Is Involved in Species-Specific Actions ofSalmonellaLipid AInfection and Immunity, 2002
- Essential role of MD-2 in LPS responsiveness and TLR4 distributionNature Immunology, 2002
- TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial CellsJournal of Biological Chemistry, 2002
- Human Toll-like receptor 4 recognizes host-specific LPS modificationsNature Immunology, 2002
- Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor ComplexJournal of Biological Chemistry, 2001
- Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient MiceImmunity, 1996