Immune Response in Vitro to Salmonella H-Antigens, Not Affected by Anti-Theta Serum

Abstract

Treatment of mouse spleen cells with antiserum cytotoxic to theta antigens does not affect the subsequent immune response in vitro to Salmonella H-antigens. Similarly treated cells fail to initiate an immune response to sheep erythrocytes. This finding represents a strong argument for the existence of immune responses to certain antigens which do not require thymus-derived cells.