The molecular biology of immunoglobulin D
- 2 February 1984
- journal article
- Published by Springer Nature in Nature
- Vol. 307 (5950), 417-422
- https://doi.org/10.1038/307417a0
Abstract
Immunoglobulin D (IgD) is co-expressed with immunoglobulin M (IgM) on the membranes of most B cells, yet its biological function has remained a mystery. Recent detailed information on the structure and transcription of the unusual IgD heavy chain (delta) gene in mouse suggests a complex genetic control. A model is presented for the developmental regulation of IgM and IgD and roles suggested for the membrane and secreted forms of IgD in the immune network.Keywords
This publication has 92 references indexed in Scilit:
- Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class SwitchingImmunological Reviews, 1982
- A model for the molecular requirements of immunoglobulin heavy chain class switchingNature, 1982
- Mouse spleen and IgD-secreting plasmacytomas contain multiple IgD δ chain RNAsNature, 1982
- Transcription and RNA processing by the DNA tumour virusesNature, 1980
- Mouse Immunoglobulin D: Messenger RNA and Genomic DNA SequencesScience, 1980
- Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptorsThe Journal of Experimental Medicine, 1980
- Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells.The Journal of Experimental Medicine, 1978
- Correlations between Three-dimensional Structure and Function of ImmunoglobulinsCRC Critical Reviews in Biochemistry, 1978
- Immunoglobulin-Receptors RevisitedScience, 1975
- Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny.The Journal of Experimental Medicine, 1975