Effects of Benadryl on Anaphylactic and Histamine Shock in Rabbits and Guinea Pigs

Abstract

Summary 1. Benadryl offers effective protection against histamine shock in rabbits. 2. Benadryl did not protect against anaphylactic shock in rabbits sensitized to egg white. 3. Benadryl did not protect guinea pigs actively sensitized to egg white against anaphylaxis induced by intraperitoneal administration of the antigen under the dosage conditions employed.