Role of Growth Hormone in Diabetes Mellitus

Abstract

Numerous studies of both laboratory animals and human beings have implicated poor glycemic control as a risk factor for development of the so-called long-term complications of diabetes mellitus (neuropathy, nephropathy, retinopathy, and premature atherosclerosis).^{1 , 2} The uncertainty that still exists derives primarily from two factors: the lack of an unequivocal demonstration that good glycemic control can diminish the severity or frequency of long-term complications in human beings³ (currently being addressed by the Diabetes Control and Complications Trial, a prospective randomized study sponsored by the National Institutes of Health), and the lack of knowledge concerning the mechanism or mechanisms by which poor . . .