The Gamma Globulins and Their Clinical Significance
- 1 January 1959
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 260 (1), 21-27
- https://doi.org/10.1056/nejm195901012600105
Abstract
IN 1948 Arne Tiselius was awarded the Nobel Prize for having developed the technic of electrophoresis, which separates the serum proteins into four major fractions: albumin, and three distinct globulins named alpha, beta and gamma. Since Tiselius1 first identified the gamma globulins as the major antibody proteins, progress in elucidating their physiologic and clinical significance has advanced steadily. Measurement of changes in the amount of serum gamma globulins has proved useful in the diagnosis of disease, and the development of practical plasma-fractionation technics by E. J. Cohn and his co-workers in the early nineteen forties has provided human gamma globulins . . .Keywords
This publication has 47 references indexed in Scilit:
- GAMMA GLOBULINS IN GERM-FREE RATSThe Journal of Experimental Medicine, 1958
- Localization of blocking antibody in sera of ragweed-sensitive individuals by starch electrophoresisJournal of Allergy, 1957
- Chromatography of Proteins. II. Fractionation of Serum Protein on Anion-exchange CelluloseJournal of the American Chemical Society, 1956
- STUDIES ON ANTIBODY PRODUCTIONThe Journal of Experimental Medicine, 1955
- STUDIES ON ANTIBODY PRODUCTIONThe Journal of Experimental Medicine, 1955
- IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINSThe Journal of Experimental Medicine, 1955
- THE LOCALIZATION OF HOMOLGOUS PLASMA PROTEINS IN THE TISSUES OF YOUNG HUMAN BEINGS AS DEMONSTRATED WITH FLUORESCENT ANTIBODIESThe Journal of Experimental Medicine, 1953
- THE HALF-LIFE OF HOMOLOGOUS GAMMA GLOBULIN (ANTIBODY) IN SEVERAL SPECIESThe Journal of Experimental Medicine, 1952
- THE EFFECT OF CORTISONE AND ADRENOCORTICOTROPHIC HORMONE ON THE CONCENTRATION OF CIRCULATING ANTIBODYThe Journal of Experimental Medicine, 1951
- A Quantitative Study of Reversible Boundary Spreading in the Electrophoresis of Proteins1Journal of the American Chemical Society, 1948