This paper is a clinical study of seventy-five cases of epithelioma of the penis in which examination and treatment were given in the department of urology of the Memorial Hospital in New York. ETIOLOGY The ages of the patients at the time of onset of the disease ranged between 21 and 79, with the decades represented as follows: between 20 and 30 years, 8 per cent; between 30 and 40 years, 13 per cent; between 40 and 50 years, 23 per cent; between 50 and 60 years, 29 per cent; between 60 and 70 years, 17 per cent, and between 70 and 80 years, 9 per cent. Seventy per cent of the patients were married, 11 per cent were widowers and 19 per cent were single. They had engaged in every type of occupation. Nine per cent were negroes and 91 per cent were white. No Jews appeared in this