Influence of Cobaltous Chloride on Aortic Atheromatosis and Plasma Lipid Pattern in Cholesterol-Fed Chickens
- 1 July 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 98 (3), 474-477
- https://doi.org/10.3181/00379727-98-24080
Abstract
Feeding of cobaltous chloride to cholesterol-fed chickens reduced the incidence and severity of their aortic lesions and caused blood cholesterol concentrations to be lower than in controls. The amounts of cholesterol in [beta]-lipoprotein were similarly reduced and [image] ratios were increased. There was no consistent effect on lipid phosphorus concentrations. Cobalt in the diet did not seem to influence the activity of the thyroid. When given either in the diet or intravenously, cobalt did not change the structure of the pancreatic [alpha]-cells. Subcutaneous injection of cobaltous chloride generally increased the incidence and severity of aortic lesions and the concentration of cholesterol in blood. The influence of cobalt in the diet on lipid pattern and aortic lesions was opposite to that of parenterally administered cobalt. It did not produce other effects indicative of previously reported specific systemic actions. It is concluded here that the effect of cobalt in the diet of cholesterol-fed chickens similarly is due to a local action in the intestinal tract.Keywords
This publication has 10 references indexed in Scilit:
- Lipid Patterns and Atherogenesis in Cholesterol-Fed ChickensExperimental Biology and Medicine, 1957
- INFLUENCE OF DIETARY MAGNESIUM ON CARDIAC AND RENAL LESIONS OF YOUNG RATS FED AN ATHEROGENIC DIETThe Journal of Experimental Medicine, 1957
- INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSISThe Journal of Experimental Medicine, 1957
- Effect of Ingested Vanadium on Cholesterol and Phospholipid Metabolism in the Rabbit.Experimental Biology and Medicine, 1956
- PANCREATIC ALPHA-CELL FUNCTION IN RELATION TO CHOLESTEROL METABOLISM*Journal of Clinical Endocrinology & Metabolism, 1956
- REDUCTION OF EXCESS CHOLESTEROL IN THE RABBIT AORTA BY INHIBITION OF ENDOGENOUS CHOLESTEROL SYNTHESISThe Journal of Experimental Medicine, 1956
- EFFECT OF CERTAIN TRANSITION GROUP ELEMENTS ON HEPATIC SYNTHESIS OF CHOLESTEROL IN THE RATJournal of Biological Chemistry, 1954
- A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITYJournal of Biological Chemistry, 1952
- CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XL. QUANTITATIVE SEPARATION AND DETERMINATION OF THE PROTEIN COMPONENTS IN SMALL AMOUNTS OF NORMAL HUMAN PLASMA 1JCI Insight, 1951
- Observations with differential stains on human islets of Langerhans1941