Variability in caffeine metabolism
- 1 May 1983
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 33 (5), 591-602
- https://doi.org/10.1038/clpt.1983.80
Abstract
Urinary metabolites excreted after oral caffeine were quantified in a healthy sample (n = 68) by HPLC [high performance liquid chromatography] analyses. The profile of metabolites, assessed by examining particular metabolite ratios, differed widely among subjects. Ratios denoting cytochrome P-450-dependent activities were interethnically variable between Oriental and Caucasian groups, whereas those indicative of xanthine oxidase activity exhibited neither significant interindividual variation nor an ethnic difference. A ratio providing an index of polymorphic N-acetyltransferase activity holds promise as a simple marker for acetylator status in man.This publication has 25 references indexed in Scilit:
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