In vivo19F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat
- 1 June 1990
- journal article
- review article
- Published by Wiley in NMR in Biomedicine
- Vol. 3 (3), 120-123
- https://doi.org/10.1002/nbm.1940030304
Abstract
In vivo 19F NMR measurements of trifluorinated neuroleptics in the rat brain were made using a 13 × 18 mm surface coil at 4.7 T. The signal of fluphenazine was obtained within 8–15 min from brains of living rats treated chronically with drug doses of 5–30 mg/kg. Following the intravenous injection of a single dose of trifluoperazine (30 mg/kg), brain levels could be monitored with a time resolution of 30 min. The data demonstrate the possibility of obtaining in vivo pharmacokinetics of fluorinated agents in the rat brain. 19F NMR is expected to become an important tool in neurochemical research.Keywords
This publication has 9 references indexed in Scilit:
- Rapid 19F magnetic resonance imaging of perfluorooctyl bromide in vivoMagnetic Resonance Imaging, 1988
- Chain-Fluorinated polyamines as tumour markers. iii. determination of geminal difluoropolyamines and their precursor 2,2-difluoroputrescine in normal tissues and experimental tumours byin vitro andin vivo19f NMR spectroscopyNMR in Biomedicine, 1988
- Proton decoupled fluorine nuclear magnetic resonance spectroscopy in situBiophysical Journal, 1987
- Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithineMagnetic Resonance in Medicine, 1987
- 19F NMR imaging of a fluorinated anesthetic in a model systemJournal of Magnetic Resonance (1969), 1986
- Fluorinated psychopharmacological agents: Noninvasive observation by flourine-19 nuclear magnetic resonancePsychiatry Research, 1986
- Plasma Level Monitoring of Antipsychotic Drugs Clinical UtilityClinical Pharmacokinetics, 1986
- Kinetics of [3H] Trifluoperazine in Bile Fistula RatsXenobiotica, 1978