The role of DNA synthesis and mitosis in hormone-dependent differentiation.
- 1 October 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (4), 1283-1289
- https://doi.org/10.1073/pnas.56.4.1283
Abstract
Mammary-gland epithelial cells must first divide in order to synthesize casein in response to insulin, hydrocortisone, and prolactin. Epithelial cells produced in medium containing insulin as the only hormone addition fail to express differentiative function. It is proposed that cell division may make a cell especially susceptible to environmental factors capable of eliciting changes in cell function.Keywords
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