Inhibition of Enzymatic Synthesis of Epinephrine by Low Doses of Glucocorticoids
- 1 May 1967
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 80 (5), 825-828
- https://doi.org/10.1210/endo-80-5-825
Abstract
Low doses of dexamethasone depress the activity of the epinephrine-forming enzyme, phenylethanolamine-N-methyl transferase, in the rat adrenal medulla; they also decrease its content of epinephrine. This inhibition can be blocked by the concurrent administration of small amounts of ACTH. Very high doses of the steroid do not lower the enzyme activity, nor do they depress the catecholamine content in the adrenal.This publication has 5 references indexed in Scilit:
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- Fluorometric Determination of Corticosterone and Cortisol in 0.02–0.05 Milliliters of Plasma or Submilligram Samples of Adrenal Tissue1Endocrinology, 1964
- Purification and Properties of Phenylethanolamine-N-methyl TransferaseJournal of Biological Chemistry, 1962