(-)Pentobarbital Opens Ion Channels of Long Duration in Cultured Mouse Spinal Neurons
- 25 July 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4455), 507-509
- https://doi.org/10.1126/science.6248961
Abstract
Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.Keywords
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