Severe Suppression of the B‐cell System has No Impact on the Maturation of Natural Killer Cells in Mice
- 1 February 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 9 (2), 167-173
- https://doi.org/10.1111/j.1365-3083.1979.tb02719.x
Abstract
Mice were treated with a heterologous anti-IgM serum to obtain B-cell-deprived mice. Spleen cells from normal and B-cell-deprived mice were tested in three different cytolytic systems: natural killer cells (NK); antibody-dependent cell-mediated cytolysis (ADCC) against an NIC-sensitive tumour, P815; and ADCC against chicken erythrocytes. The impact of administration of an interferon-inducing NK enhancing agent, Tilorone, was also investigated. Whereas the cell population from B-cell-deprived mice was significantly suppressed in antibody-producing cells, the capacity to function in NK or ADCC was largely unimpaired both before and after administration of Tilorone. Our results would imply that mature B cells play no significant role in either the maturation of the NK cells or the expression of their cytolytic ability. Furthermore, effector cells for both NK and ADCC against antibody-coated tumour target cells were found to be distinct from those functioning in ADCC against chicken erythrocytes.This publication has 22 references indexed in Scilit:
- In Vivo Generation of Mouse Natural Killer Cells: Role of the Spleen and ThymusScandinavian Journal of Immunology, 1978
- Natural Killer Cells may be the Only Cells in Normal Mouse Lymphoid Cell Populations Endowed with Cytolytic Ability for Antibody‐Coated Tumour Target CellsScandinavian Journal of Immunology, 1978
- Natural cytotoxicity to human leukemia mediated by mouse non-t cellsInternational Journal of Cancer, 1977
- A plaque assay for all cells secreting Ig of a given type or classEuropean Journal of Immunology, 1976
- Immunoglobulin-bearing cells in bone marrow of mice after prolonged treatment with anti-IgM antibodiesNature, 1976
- Exclusion of cooperating T cells as targets for heterologous anti-μ antiserumCellular Immunology, 1974
- PRODUCTION OF A RUNTING SYNDROME AND SELECTIVE γA DEFICIENCY IN MICE BY THE ADMINISTRATION OF ANTI-HEAVY CHAIN ANTISERAThe Journal of Experimental Medicine, 1973
- Alpine Glacial Features of MarsNature, 1973
- IMMUNOSUPPRESSION OF MICE INJECTED WITH HETEROLOGOUS ANTI-IMMUNOGLOBULIN HEAVY CHAIN ANTISERAThe Journal of Experimental Medicine, 1972
- SUPPRESSION OF IMMUNOGLOBULIN CLASS SYNTHESIS IN MICEThe Journal of Experimental Medicine, 1972