NEONATAL THYMUS GRAFTS .1. STUDIES ON THE REGULATION OF THE LEVEL OF CIRCULATING THYMIC FACTOR (FTS)
- 1 January 1979
- journal article
- research article
- Vol. 36 (2), 207-213
Abstract
The level of FTS, tested by its action on spleen rosette-forming cells from adult thymectomized mice, was stable in young animals. This stability suggests a regulatory mechanism. The FTS level was disrupted by neonatal thymus grafting in adult normal and thymectomized animals or by injections of synthetic thymic factor into normal, thymectomized mice, grafted or ungrafted. After an initial increase over the normal value, FTS levels returned close to the previous range, indicating the existence of some homeostatic mechanism of FTS secretion.This publication has 14 references indexed in Scilit:
- Structural study of circulating thymic factor: a peptide isolated from pig serum. II. Amino acid sequence.Journal of Biological Chemistry, 1977
- Lymphocyte-Mediated Cytotoxicity: Effects of Ageing, Adult Thymectomy and Thymic FactorThe Journal of Immunology, 1977
- Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.Proceedings of the National Academy of Sciences, 1977
- In vitro responses of rat lymphocytes following adult thymectomy III. Prevention by thymic factor of increased suppressor activity in the spleenCellular Immunology, 1976
- ONTOGENY OF THYMUS FACTOR SECRETION1976
- THE ISOLATION OF THYMOPOIETIN (THYMIN)*Annals of the New York Academy of Sciences, 1975
- Studies on thymus products. II. Demonstration and characterization of a circulating thymic hormone.1973
- Studies on thymus products. I. Modification of rosette-forming cells by thymic extracts. Determination of the target RFC sub-population.1973
- Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.1973
- THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTSImmunology & Cell Biology, 1963