THE SWEAT gland of the sole is uniquely protected from external forces. A relatively immense keratinous barrier cushions physical and chemical trauma, and the absence of the pilosebaceous apparatus insures minimal absorption of chemicals and drugs. Because of these exceptional anatomic considerations, it is impossible to include the plantar sweat gland in any generalization regarding the dermatology therapeutic effect of topical agents or measures. Relatively little experimental data have appeared in the literature regarding the effects of topical measures and medicaments on the normal sweat gland of the soles in man.1 Accordingly, the present study was initiated to obtain further information on this point.