Prodolic Acid: Analysis and Disposition Studies in Rats and Dogs
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 7 (6), 329-337
- https://doi.org/10.3109/00498257709035791
Abstract
1. A specific fluorimetric method for the determination of prodolic acid in serum has been elaborated and has a limit of detection of 2 μg/mL 2. Common anti-inflammatory drugs do not interfere with the method. 3. In rats and dogs, prodolic acid is rapidly absorbed and has a short half-life of elimination. 4. The rate of elimination was marked by secondary rises in the blood level profile which were shown to be due to enterohepatic recirculation of prodolic acid. 5. Prodolic acid is highly bound to serum protein.This publication has 3 references indexed in Scilit:
- Investigation of 1,3,4,9-tetrahydro-1-propylpyrano [3, 4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats1)Inflammation Research, 1974
- The biliary excretion of tartrazine. Sex differences in the rat and species differences in the rat, guinea-pig and rabbitJournal of Pharmacy and Pharmacology, 1972
- A procedure for computer analysis of data from macromolecule-ligand binding studiesComputers and Biomedical Research, 1968