Preferential X inactivation in human placenta membranes: Is the paternal X inactive in early embryonic development of female mammals?
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 43 (3), 265-273
- https://doi.org/10.1007/bf00278833
Abstract
In placenta membranes of newborn girls carrying electrophoretically distinguishable G6PD alleles, the maternally derived isozyme is expressed preferentially. This phenomenon cannot be explained by allelic differences in enzyme activity or by somatic selection directed against cells with particular G6PD phenotypes. Instead, it may be that in this tissue X inactivation is nonrandom. Preferential expression of the maternal X chromosome, as has been shown in marsupials and in extraembryonic membranes of rodents and now in man, may reflect the state of activity of the X chromosomes in the early stages of female embryonic development.Keywords
This publication has 29 references indexed in Scilit:
- X chromosome inactivation in diploid parthenogenetic mouse embryosNature, 1978
- X–chromosome inactivation during differentiation of female teratocarcinoma stem cells in vitroNature, 1978
- X inactivation, differentiation, and DNA methylationCytogenetic and Genome Research, 1975
- Differentiation of X chromosomes in early female mouse embryosExperimental Cell Research, 1974
- Two functional X chromosomes in human fetal oocytesExperimental Cell Research, 1973
- Expression of the Mammalian X Chromosome before and after FertilizationScience, 1972
- Non-Random Late Replication of X Chromosomes in Mules and HinniesNature, 1971
- Non-random X Chromosome Expression in Female Mules and HinniesNature, 1971
- Biological Sciences: X Chromosome Inactivation studied by Injection of a Single Cell into the Mouse BlastocystNature, 1971
- The temporal appearance of sex chromatin and of the late-replicating X chromosome in blastocysts of the domestic rabbitCytogenetic and Genome Research, 1969