Encapsulation of macromolecules by lipid vesicles under simulated prebiotic conditions
- 1 May 1982
- journal article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 18 (3), 203-206
- https://doi.org/10.1007/bf01733047
Abstract
Phospholipid vesicles (liposomes) were subjected to dehydration-hydration cycles in the presence of 6-carboxyfluorescein or salmon sperm DNA. We found that the vesicles fused into multilamellar structures during dehydration with solutes trapped between the lamellae. Upon rehydration the lamellae swelled and formed large vesicular structures containing solute. This model can be used to study encapsulation of macromolecules by lipid membranes to form protocellular structures under prebiotic conditions.Keywords
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