The possible role of coenzyme A in the biosynthesis of cholesterol in the rat
- 1 December 1953
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 55 (5), 892-895
- https://doi.org/10.1042/bj0550892
Abstract
It was observed that if rats are maintained on a fat-free diet, the liver ester cholesterol concn. and the plasma ester cholesterol concn. appear dependent on dietary pantothenate and hence on the coenzyme-A content of the tissues. The presence of neutral fat in the diet can annul these effects. It is concluded that the synthesis of cholesterol from acetate is dependent on coenzyme A.Keywords
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