Cytopathic Effect of Simian Virus 40 on Primary Cell Cultures of Rhesus Monkey Kidney
- 31 October 1964
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 93 (5), 716-724
- https://doi.org/10.4049/jimmunol.93.5.716
Abstract
It was found that SV-40 grows progressively to high titers in cultures of rhesus monkey kidney, and destroys the cell monolayers. This process takes several weeks. Incubation at reduced temperature (26 to 28°C) slows viral multiplication and consequent cell destruction. Electron microscopic observations indicate that the intranuclear development of SV-40 does not differ significantly from its development in cells in which it exerts a more rapid and distinctive cytopathic effect.Keywords
This publication has 3 references indexed in Scilit:
- Biologic Characteristics of a Continuous Kidney Cell Line Derived from the African Green MonkeyThe Journal of Immunology, 1963
- EVIDENCE OF CONTINUOUS TRANSMISSION OF NONINFECTIOUS SV 40 VIRAL GENOME IN MOST OR ALL SV 40 HAMSTER TUMOR CELLSProceedings of the National Academy of Sciences, 1963
- Transformation in hamster kidney monolayers by vacuolating virus, SV-40Virology, 1963