THE INFLUENCE OF THYROID, DINITROPHENOL AND SWIMMING ON THE GLYCOGEN AND PHOSPHOCREATINE LEVEL OF THE RAT HEART IN RELATION TO CARDIAC HYPERTROPHY

Abstract

Both glycogen and phosphocreatine were present in low concs. in the hypertrophied hyperthyroid rat heart. Dinitrophenol administered subcut. for a period of 2 wks. failed to produce an increase in the heart wt. of rats. Young rats which had been swimming 3.3 hrs. daily for about 2 mos. showed moderate cardiac hypertrophy. When detd. 1-24 hrs. after swimming the cardiac glycogen was normal or elevated. When the animals had been fasted and rested 24 hrs. after swimming the cardiac glycogen conc. averaged twice as high as normal.