The Fixation of Radioactive Digitoxin by Isolated Hearts
- 1 July 1951
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 4 (1), 100-104
- https://doi.org/10.1161/01.cir.4.1.100
Abstract
The nature of digitoxin fixation in isolated hearts was studied with C14 labelled digitoxin. Fixation was greatest in the early stages of perfusion. The amount of drug fixed was measured directly. A considerable percentage of the digitoxin in cardiac muscle was changed to other substances. These substances are more firmly bound to the heart than digitoxin.Keywords
This publication has 6 references indexed in Scilit:
- An Internal Geiger Counter for the Assay of Low Specific Activity Samples of Carbon 14 and other Weak Beta Emitters in Biological SamplesScience, 1949
- Quantitative Detection of Minute Concentrations of Digitoxin.Experimental Biology and Medicine, 1948
- Biosynthesis of Radioactive Drugs Using Carbon 14Science, 1948
- The Delay in the Action of Digitalis Glycoside (Lanatoside C.)Experimental Biology and Medicine, 1948
- Reversibility of Digitalis Action.Experimental Biology and Medicine, 1940
- Über Aufnahme und Speicherung der Digitalissubstanzen im HerzenNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1915