Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutans
- 1 May 1975
- journal article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 54 (3), 433-440
- https://doi.org/10.1177/00220345750540030301
Abstract
Studies on the effect of various structural analogues of glucose of phosphoenolpyruvate (PEP)-dependent sugar transport in Streptococcus mutans showed that sugars with alterations at carbon 2 were markedly inhibitory. Low concentrations of the non-fermentable analogue D -2-deoxyglucose (2-deoxyG) blocked the growth of S mutans in broth media containing various fermentable sugars. Acid production by S mutans from. both exogenous glucose and intracellular storage polysaccharide was inhibited by 2-deoxyG. The analogue is bacteriostatic, and large quantities of intracellular 2-deoxyG-6-PO4 accumulate during exposure of S mutans to the sugar.Keywords
This publication has 25 references indexed in Scilit:
- Effect of Sugar Analogues on Growth, Sugar Utilization, and Acid Production by Streptococcus mutansJournal of Dental Research, 1975
- Phosphoenolpyruvate-Dependent Glucose Transport in Oral StreptococciJournal of Dental Research, 1973
- Studies on the Uptake of Hexose PhosphatesPublished by Elsevier ,1971
- PYRANOSE–FURANOSE AND ANOMERIC EQUILIBRIA: INFLUENCE OF SOLVENT AND OF PARTIAL METHYLATIONCanadian Journal of Chemistry, 1966
- 10. The structure and conformation of some monosaccharides in solutionJournal of the Chemical Society, 1965
- PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEMProceedings of the National Academy of Sciences, 1964
- Simplified Way to Cultivate Chick Kidney Cells and Maintain the Culture without SerumScience, 1959
- Introduction: Structure and Stereochemistry of the MonosaccharidesPublished by Elsevier ,1957
- Detection of Sugars on Paper ChromatogramsNature, 1950
- The Shape of Pyranoside RingsJournal of the American Chemical Society, 1950