The effect of carbamazepine on serum immunoglobulin concentrations

Abstract

Serum IgA, IgG and IgM concentrations were determined in 30 patients with partial epilepsy before and during carbamazepine therapy. None received antiepileptic drugs prior to the study. The IgA and IgM concentrations decreased significantly during the 1st mo. of treatment (P < 0.0001). No further decrease was observed during the subsequent 3 mo. In 15 patients followed for 8-30 mo., the IgA concentrations remained low, while the IgM concentrations tended to increase. IgM concentrations did not reach the levels which were found before carbamazepine was started. Carbamazepine had no influence on the mean IgG serum concentration. There was no relationship between the IgA and IgM concentrations in serum and the serum concentrations of carbamazepine.