Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits
- 27 July 2003
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 6 (9), 911-912
- https://doi.org/10.1038/nn1101
Abstract
Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks1,2 is correlated with substantial changes in neuronal signal processing in the hippocampus3,4,5. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task6,7.Keywords
This publication has 16 references indexed in Scilit:
- An open and shut caseNature, 2002
- Age-related biophysical alterations of hippocampal pyramidal neurons: implications for learning and memoryAgeing Research Reviews, 2002
- Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ ChannelsJournal of Biological Chemistry, 2001
- Ca2+-activated K+ currents in neurones: types, physiological roles and modulationTrends in Neurosciences, 1996
- Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 ratsHippocampus, 1993
- Chapter 12 Potassium currents in hippocampal pyramidal cellsPublished by Elsevier ,1990
- Prolonged Ca 2+ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged RatsScience, 1984
- Spatial memory deficit in senescent rats.Canadian Journal of Psychology / Revue canadienne de psychologie, 1980
- Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient ratsBrain Research, 1978