Influence of Cortisone, Pironlen and ACTH on Susceptibility of Embryonated Eggs to Fowl-Pox Virus

Abstract

An investigation to examine the influence and interrelationship of cortisone, piromen and ACTH upon the susceptibility of the embryonated egg to parasitism by the fowl-pox virus was undertaken. It was found that the pre- and post-treatment of eggs with cortisone by the chorioallantoic and allantoic cavity routes decreased the susceptibility of the chorioallantois to infection and retarded the development of the individual lesions. These effects were not observed if piromen or ACTH were substituted for the cortisone. Simultaneous treatment of eggs with cortisone and piromen or ACTH resulted in inhibition of the effects found with cortisone alone. Moreover, the reduction in size of lesions, although discernible, was not as pronounced as with cortisone.