Antimycobacterial ActivityIn Vivoof LM427 (Rifabutin)
- 1 November 1988
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 138 (5), 1254-1257
- https://doi.org/10.1164/ajrccm/138.5.1254
Abstract
The activity of the rifampin derivative rifabutin (ansamycin; LM427) was tested in vivo against experimental infections of mice with members of the Mycobacterium avium complex (MAC) and a highly virulent strain of tuberculosis. Rifabutin was moderately effective against an environmental serotype 8 strain of MAC and of significant effectiveness against low dose aerogenic infections with two strains of higher virulence. The drug was also highly effective in causing the rapid resolution of an intravenous M. tubercuiosis infection. These data thus contest a previous negative report on the activity of rifabulin in mouse models of M. avium complex.This publication has 8 references indexed in Scilit:
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