Central nervous system amplification
- 1 April 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 32 (4), 359
- https://doi.org/10.1212/wnl.32.4.359
Abstract
Ability to record a sizable somatosensory evoked potential (SEP) in the absence of a recordable sensory nerve action potential (SNAP) suggests a normally occurring central nervous system amplifying process. Increments in SEP and SNAP amplitude with increasing stimulus strength between threshold and 2.5 times threshold (maximum) were compared. At threshold (40% of maximum stimulus) and 50% maximum stimulus, amplification measured 2.3 ± 0.7 and 2.0 ± 0.6, respectively. In 21 MS patients, the SEP at threshold stimulation was absent in 15, but normal in 5 of these at maximum stimulation. It is postulated that normal central amplification is markedly attenuated in MS, and this may be a sensitive indicator of early disease.This publication has 8 references indexed in Scilit:
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