Glucose Tolerance in Relation to Obesity and Food Intake

Abstract

Glucose tolerance tests were carried out on two strains of mice, one highly susceptible, the other only moderately susceptible to nutritional obesity. With glucose administered on the basis of body weight or fat-free weight, the highly susceptible strain disposed more rapidly of the administered glucose than did the moderately susceptible strain. Fasting blood sugar levels in both strains were found to increase with the logarithm of body weight. These observations are not readily explained in terms of the ‘glucostatic’ theory of the control of food intake.