Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. A quantitative analysis in the cat
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in Experimental Brain Research
- Vol. 55 (3), 483-493
- https://doi.org/10.1007/bf00235279
Abstract
Previous experiments have shown that the ERG response to alternating gratings vanishes gradually within 4 months after transection of the optic nerve, changes begin after 2–3 weeks. The response to gratings of low spatial frequencies deteriorates earlier than the response to gratings of high spatial frequencies (Maffei and Fiorentini 1981). Quantitative analysis of ganglion cell sizes in retinal wholemounts shows that ganglion cell shrinkage and ganglion cell loss begin at three weeks in the periphery of the retina, particularly in the temporal retina. The same morphological alteration subsequently becomes apparent also in the area centralis and the nasal retina, respectively. The main and early cell loss occurs among medium sized ganglion cells, supposedly the beta-cells. Among the alpha-cells only shrinkage is observed up to two months postoperatively. Light- and electron microscopic examination of cross sections through the retina show that pathological changes are restricted to the innermost layers.Keywords
This publication has 27 references indexed in Scilit:
- Electroretinographic responses to alternating gratings in the catExperimental Brain Research, 1982
- Loss of Retinal X-cells in Cats with Neonatal or Adult Visual Cortex DamageScience, 1982
- Transneuronal retrograde degeneration in the cat retina following neonatal ablation of visual cortexBrain Research, 1981
- AGE-CORRELATED DIFFERENCES IN THE AMOUNT OF RETINAL DEGENERATION AFTER STRIATE CORTEX LESIONS IN MONKEYS1981
- Evidence for the loss of X-cells of the retina after long-term ablation of visual cortex in monkeysBrain Research, 1979
- The effect of superior colliculus lesions upon the visual fields of cats with cortical ablationsJournal of Comparative Neurology, 1977
- A quantitative analysis of the cat retinal ganglion cell topographyJournal of Comparative Neurology, 1975
- The distribution of the alpha type of ganglion cells in the cat's retinaJournal of Comparative Neurology, 1975
- Simultaneous recording of pre- and postsynaptic potentials during the degeneration of the optic tract fiber input to the lateral geniculate nucleus of catsBrain Research, 1974
- Atrophy of Retinal Ganglion Cells after Removal of Striate Cortex in a Rhesus MonkeyPerception, 1974