Compressed microfibril models of the native collagen fibril
- 1 July 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 286 (5770), 300-301
- https://doi.org/10.1038/286300a0
Abstract
A three-dimensional crystal model for packing of collagen molecules (type I) in the native fibril has recently been proposed by Hulmes and Miller. It provides a straightforward explanation of the major features of the X-ray diffraction pattern, and is consistent with measurements of fibril density. However, there is independent evidence for a well defined microfibrillar substructure, which is absent from their model. This evidence, which is derived from electron microscopy and studies of in vitro assembly, the pattern of covalent crosslinks and sequence analysis, is convincing. Therefore, we have searched for a means to reconcile this conflict. We now propose two models which contain five-stranded microfibrils compressed to place molecules (in cross-section) on a pseudohexagonal lattice. The unit cells are equivalent or related to the cell proposed by Hulmes and Miller. In the simplest case, molecules, and thus microfibrils, are straight-tilted. However, it is not ruled out that molecules are supercoiled and microfibrils are straight. Noncrystallographic considerations favour supercoiling.Keywords
This publication has 15 references indexed in Scilit:
- The chemistry of the collagen cross-links. Purification and characterization of cross-linked polymeric peptide material from mature collagen containing unknown amino acidsBiochemical Journal, 1980
- Quasi-hexagonal molecular packing in collagen fibrilsNature, 1979
- Electron microscope evidence for an 80 Å unit in collagen fibrilsNature, 1979
- Collagen fibrils with straight and helicoidal microfibrils: a` freeze-fracture and thin-section studyJournal of Ultrastructure Research, 1979
- Molecular assembly in collagenFEBS Letters, 1978
- Sequence regularities and packing of collagen moleculesJournal of Molecular Biology, 1978
- The structure of collagen fibrilsJournal of Supramolecular Structure, 1974
- Structure and packing of microfibrils in collagenJournal of Molecular Biology, 1973
- Molecular Packing in CollagenNature, 1971
- Molecular Pattern in Native CollagenNature, 1968