System Evaluation and Substance Identification in Systematic Toxicological Analysis by the Mean List Length Approach

Abstract

In systematic toxicological analyses (STA), analytical methods are needed with a high identification Power. The mean list length (MLL) approach, which is an Improved and extended version of the identification Power concept, provides an objective tool for the evaluation and optimum choice of analytical methods for STA. The MLL approach is elucidated and applied to the screening for basic drugs by thin layer chromatography (TLC) and gas-liquid chromatography (GLC). Its usefulness for TLC and GLC systems for the identification of these basic drugs has been evaluated for both single systems and combinations of systems. The MLL approach is also substance directed and can be applied to computerized data searches and substance identification. The method Is applicable for single analytical systems and combinations of systems. Mixtures of substances can also be handled.