SHORT COMMUNICATION: Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe—NTA)
- 1 February 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 11 (2), 345-347
- https://doi.org/10.1093/carcin/11.2.345
Abstract
A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe—NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum — nitrilotriacetate complex (A1—NTA), non-complexed NTA (Na2NTA) and ferric chloride had no effect on 8-OH-dG production in the kidney DNA. These results suggest the involvement of active oxygen radicals in Fe—NTA carcinogenesis.This publication has 12 references indexed in Scilit:
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