ASPECTS OF PARIETAL CELL BIOLOGY: CELLS AND VESICLES
- 1 May 1980
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 341 (1), 312-334
- https://doi.org/10.1111/j.1749-6632.1980.tb47181.x
Abstract
Many features of these gastric vesicles satisfy the requirements for the gastric H+ pump. For example, we have: (a) K+ requirement, (b) KA for K+ of about 30 mM; (c) identical cation sequence for tissue and vesicles, (d) similar anion sequence, (e) localization at the microvillus of the secretory canaliculus, (f) TI+ inhibiting H+ transport of both systems, and (g) the K+ gradient satisfying the osmotic gradient requirement for HCl-flow out of the parietal cell. Points that require explanation are lack of SCN- effects and regulation of KCl permeability.Keywords
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