Subclasses of external adenosine receptors.
- 1 May 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (5), 2551-2554
- https://doi.org/10.1073/pnas.77.5.2551
Abstract
Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], and the receptors that mediate these different responses can be discriminated with selected adenosine analogs. 5''-N-Ethylcarboxamide-adenosine is a more potent agonist at stimulatory receptors than is N6-phenylisopropyladenosine, whereas the reverse potency order is seen with inhibitory receptors. The potency of adenosine is intermediate between the potencies of these 2 analogs. The relative potencies of adenosine receptor agonists are maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis. As with adrenergic receptors, subclasses of adenosine receptors differ functionally and pharmacologically. Experiments were performed with rat hepatocytes, adipocytes and mouse Leydig cell tumor I-10 cells.This publication has 22 references indexed in Scilit:
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