Effects of Inhibitors of Nucleic Acid and Protein Synthesis on Ethyl Methanesulfonate-Induced Sister Chromatid Exchanges in Chinese Hamster Cells

Abstract

DNA synthesis inhibitors enhanced and protein synthesis inhibitors reduced the frequency of sister chromatid exchanges induced by the alkylating agent, ethyl methanesulfonate in Chinese hamster cells. The synergism and antagonism mainly occured when cells were exposed to these agents during the first half of the S phase.