EFFECTS OF GROWTH HORMONE RELEASE-INHIBITING HORMONE AND BROMOCRYPTINE (CB 154) IN STATES OF ABNORMAL PITUITARY-ADRENAL FUNCTION
- 29 February 1976
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 5 (2), 187-190
- https://doi.org/10.1111/j.1365-2265.1976.tb02831.x
Abstract
Growth hormone release-inhibiting hormone (GHR-IH) was administered to 5 patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in 2 patients who had undergone bilateral adrenalectomy because of Cushing''s disease; 1 of them had Nelson''s syndrome. Bromocryptine (2.5 mg) suppressed ACTH levels by 62-67% for more than 6 h in these patients. GHR-IH did not significantly influence cortisol secretion by an adrenal carcinoma and only slight changes were seen in 2 patients with Addison''s disease. The possible therapeutic implications are discussed.This publication has 7 references indexed in Scilit:
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