Proliferative Response of H‐2 Incompatible Leukocytes to an Abelson Virus‐Induced Lymphoma Cell Line Apparently Not Expressing Ia‐Antigens
- 1 May 1978
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 11 (5), 457-464
- https://doi.org/10.1111/j.1399-0039.1978.tb01284.x
Abstract
The proliferative response of normal lymph node cells from different mouse strains to an Abelson virus-induced leukemic cell line (MLVA) in mixed leukocyte culture (MLC) was investigated. MLVA leukemic cells stimulate a specific response. The stimulating determinants are probably controlled by genes in the K-end of the H-2 complex. Using 2 different anti-Ia sera and different assay systems, it was impossible to detect the expression of Ia-antigens on MLVA. An alloantiserum raised against MLVA, and absorbed with P815, a non-stimulating mouse mastocytoma cell line, showed no residual activity against MLVA cells.This publication has 13 references indexed in Scilit:
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