Reduced Leucocyte Alkaline Phosphatase Activity and Decreased NBT Reduction Test in Induced Iron Deficiency Anaemia in Rabbits
- 1 November 1979
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 43 (3), 457-463
- https://doi.org/10.1111/j.1365-2141.1979.tb03773.x
Abstract
Fe deficiency anemia was induced in rabbits by repeated bleeding. The leukocyte alkaline phosphatase (LAP) of 26 .+-. 28 units [U] was significantly reduced compared with control values of 233 .+-. 36 U (P < 0.001). Leukocyte NBT reduction was also diminished, in Hanks solution (P < 0.01) and in autologous serum (P < 0.001). After administration of Fe these values returned to normal. Reduced LAP may reflect a deficiency of Fe-dependent constituents necessary for integrity of normal granulocyte metabolism.This publication has 38 references indexed in Scilit:
- Fasting (Acute Energy Deprivation) in Man: Effect on Polymorphonuclear Granulocyte Functions, Plasma Iron and Serum TransferrinScandinavian Journal of Haematology, 2009
- EFFECTS OF IRON DEFICIENCY EXCLUSIVE OF ANAEMIABritish Journal of Haematology, 1978
- Leukocyte alkaline phosphataseAmerican Journal of Hematology, 1978
- Depressed Phagocytic Function Exhibited by Polymorphonuclear Leucocytes from Chronically Iron Deficient RabbitsBritish Journal of Haematology, 1976
- Impaired immunocompetence associated with iron deficiencyThe Journal of Pediatrics, 1975
- The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral componentsThe Journal of Pediatrics, 1975
- Granulocyte Function in Chronic Granulocytic LeukaemiaBritish Journal of Haematology, 1975
- CELL-MEDIATED IMMUNITY AND PHAGOCYTOSIS AND KILLING FUNCTION IN CHILDREN WITH SEVERE IRON-DEFICIENCY ANÆMIAThe Lancet, 1974
- International Committee for Standardization in HematologyBritish Journal of Haematology, 1971
- Aseptic addition method for Lactobacillus casei assay of folate activity in human serumJournal of Clinical Pathology, 1966