A NEW AND ECONOMICAL DESICCATING PROCESS PARTICULARLY SUITABLE FOR THE PREPARATION OF CONCENTRATED PLASMA OR SERUM FOR INTRAVENOUS USE: THE ADTEVAC PROCESS

Abstract

A new process for the large scale desiccation of plasma, serum, and biological substances is described. Essentially the process consists of the removal of water vapor from the frozen state by means of vacuum. This is accomplished by the removal and binding of water vapor through the use of controlled adsorption. Water vapor to the extent of 14% of the wt. of the adsorbent was taken up in exptl. runs. A residual moisture content as low as 0.03% could be obtained by the 2-stage operation of this process. In 66 doses of concentrated plasma prepared by this method, given intraven. to 45 individuals, no harmful reactions of any sort were noted. Good clinical results were obtained in shock, hemorrhage, head injuries, and miscellaneous hypoproteinemias.