A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients
- 1 June 1994
- journal article
- clinical trial
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 89 (6), 382-389
- https://doi.org/10.1111/j.1600-0447.1994.tb01533.x
Abstract
Fifty-seven inpatients with major depression (DSM-III-R) entered a 12-week study comparing paroxetine and imipramine. Trends (not reaching statistical significance) in favour of paroxetine were seen on the Hamilton Depression Rating Scale (HDRS) and the Montgomery-Asberg Depression Rating Scale (MADRS). The UKU Side Effect Rating Scale showed a significant difference in favour of paroxetine on reduced salivation. Global evaluation of side effect symptoms showed that significantly more paroxetine patients had no side effects, both in the investigators' and the patients' opinion. These results are in line with previous findings of paroxetine being an effective and well tolerated antidepressant.Keywords
This publication has 22 references indexed in Scilit:
- A double-blind comparison of paroxetine and fluoxetine in the treatment of geriatric patients with major depressionEuropean Neuropsychopharmacology, 1992
- ParoxetineDrugs, 1991
- Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter studyJournal of Affective Disorders, 1990
- An interim overview of the safety and tolerability of paroxetineActa Psychiatrica Scandinavica, 1989
- The effects of paroxetine and other antidepressants in combination with alcohol in psychomotor activity related to car drivingHuman Psychopharmacology: Clinical and Experimental, 1988
- Determination of paroxetine in human plasma, using high-performance liquid chromatography with fluorescence detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- Study duration in antidepressant research: Advantages of a 12-week trialJournal of Psychiatric Research, 1986
- Duration of Antidepressant Drug TreatmentArchives of General Psychiatry, 1984
- Development of a Rating Scale for Primary Depressive IllnessBritish Journal of Social and Clinical Psychology, 1967
- An Inventory for Measuring DepressionArchives of General Psychiatry, 1961