Paradoxical increased feeding following glucose infusions in recovered lateral rats

Abstract

Glucose infusions increased feeding in recovered lateral hypothalamic (LH) lesioned rats in constrast to its suppressant effect in sham-lesioned rats and in rats with lesions unilateral, asymmetrical or anterior to LH. This paradoxical enhancement of eating by glucose was predicted from similar effects seen in vagotomized rabbits and general parallels observed in ingestive behavior after LH lesions and vagotomy. We conclude that an important component in the short-term control of food intake is a vagal-LH circuit and that a modification of the classic notion of the LH as an excitatory "feeding center" is needed.