A 29-year-old stenographer with interstitial cystitis has been studied. She has undergone a multiplicity of surgical assaults in an effort to be rid of the incapacitating bladder symptoms due to this disease. In spite of a technically successful cystectomy with ureteral transplants, manifold other problems remain unchanged. The psychiatric history has been related in detail in an effort to point out some possible psychosomatic elements in the etiology of her disabling disease process.