Plasmapheresis in a patient with angioimmunoblastic lymphadenopathy: Improvement in clinical and immunologic abnormalities
- 1 March 1983
Abstract
A patient with steroid resistant, allergen related angioimmunoblastic lymphadenopathy underwent a course of six plasmaphereses during a three‐week period. A 75% reduction in lymph node size along with the disappearance of her night sweats occurred. Immunologic abnormalities prior to plasmapheresis included the presence of elevated levels of circulating immune complexes, high levels of spontaneous mononuclear cell blastogenesis and abnormal mitogen responses to Conconavalin A and phytohemaglutinin. Following plasmapheresis there was a marked reduction in immune complex levels, and return of spontaneous blastogenesis and mitogen responses to normal levels. Mechanisms for the beneficial effect seen in this patient include removal of: (1) the antigenic stimulus; (2) antigen antibody complexes; and (3) other humoral factors which may modulate lymphocyte or macrophage function. Additional studies of plasmapheresis are warranted in selected patients with allergen related AIL.This publication has 22 references indexed in Scilit:
- Restoration of Defective Cellular Immunity by Levamisole in a Patient with Immunoblastic LymphadenopathyScandinavian Journal of Haematology, 2009
- Biological effects of activation of human peripheral blood mononuclear cells by mitogenic oxidizing agentsCellular Immunology, 1981
- Augmentation of proliferation and generation of specific cytotoxic cells in human mixed lymphocyte culture reactions by colchicineCellular Immunology, 1980
- Angioimmunoblastic lymphadenopathy with retinitis and drug related exacerbations.A clinicopathological case studyCancer, 1979
- PREDNISONE IN TREATMENT OF ALLERGEN-ASSOCIATED ANGIO-IMMUNOBLASTIC LYMPHADENOPATHYThe Lancet, 1979
- Immunoblastic lymphadenopathy with pulmonary infiltrates, hypocomplementemia and vasculitisAmerican Journal Of Medicine, 1977
- Prostaglandin-Producing Suppressor Cells in Hodgkin's DiseaseNew England Journal of Medicine, 1977
- Angioimmunoblastic lymphadenopathy: An immunochemical studyClinical Immunology and Immunopathology, 1976
- The Raji cell radioimmune assay for detecting immune complexes in human sera.JCI Insight, 1976
- ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINÆMIAThe Lancet, 1974